Medical Disclaimer: This website is educational and does not provide medical advice, diagnosis, or treatment. Only a qualified physician can determine whether metabolic surgery is appropriate for you.

Research

Evidence Library

A curated index of the studies, guidelines, and regulatory documents that inform the clinical content on this site.

Last medically reviewed: June 1, 2026 · Educational content only — not medical advice.

Randomized trials — metabolic surgery vs. medical therapy

  • STAMPEDE (Schauer PR et al., NEJM 2012, 2017) — Gastric bypass and sleeve gastrectomy vs. intensive medical therapy for type 2 diabetes.
  • Mingrone G et al., NEJM 2012; Lancet 2021 — 10-year outcomes of bariatric–metabolic surgery vs. medical therapy.
  • SOS Study (Sjöström L et al., NEJM 2004, 2007) — Long-term mortality after bariatric surgery.

Pharmacotherapy trials

  • STEP-1 through STEP-4 — Semaglutide for chronic weight management.
  • SURMOUNT-1 through SURMOUNT-4 — Tirzepatide for obesity and weight maintenance.
  • SUSTAIN and PIONEER program — Semaglutide in type 2 diabetes.

Society guidelines

  • ADA Standards of Care in Diabetes — updated annually.
  • AACE / ACE Clinical Practice Guidelines for Comprehensive Medical Care of Patients with Obesity.
  • ASMBS / IFSO 2022 Indications for Metabolic and Bariatric Surgery.
  • EASD / EASO joint statements on obesity and diabetes.

Regulatory documents

  • FDA — De Novo authorizations and 510(k) summaries for magnetic anastomosis devices.
  • COFEPRIS — Mexican health authority device and facility registrations.

Additional references appear on the References page and on individual content pages.